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An Introduction to vaccines!

Asher Kelman

OPF Owner/Editor-in-Chief
This is intended to be an easy introduction preventing the worst of infectious diseases that afflict is, by using our knowledge of how the body naturally defends itself against microbes.

All germs have some overcoat and “stuff in their pockets that to the human body are recognized as foreign. Such materials are generally either made up of strings of amino acids in a protein or else unique weird polymers of carbohydrates.

Our bodies have collections of cells in a defense system called immune cells which are able to make programmed production of nano-chemicals engineered time strongly attach to the foreign materials and so make them easy for other cells to inactivate and devour them.

There are two principal types of immune response. Circulating engineered nano-chemical weapons called antibodies and specialized fighting vehicle-like cells call T lymphocytes. In common, these to processes rely on

1. an ability to customize weapons against the constituent building blocks of the invading illness causing organism

2. the ability to memorize the structure of the enemy building blocks and respond rapidly with a massive armed weapon response if that foreign enemy against ever penetrates the tissues of the body in the future.

Unfortunately this brilliant defensive war mechanism takes days to dissect the building blocks of the invader and weeks to mount an effective antibody and cellular response.

In the meanwhile, the infection multiplies the pathogen and this can be released to infect many others and a whole community can be one ill or be wiped out with few survivors, in the very worst cases.

So the challenge was to use the body’s natural defense system but make it far more effective for infections that hurt us!
 

Asher Kelman

OPF Owner/Editor-in-Chief
Early vaccines!

An English physician discovered that cow maids infected with Cowpox we’re protected against often lethal Smallpox.

From this developed the idea that if one could obtain a “weaker cousin” of the dangerous microbe killing humans, then we could trick our bodies to making an effective military response well before the real dangerous infection came to that community.

This opened the war against dangerous infections by simulating actual infection by using weak natural, (or man-cultivated versions(, of dangerous invading organisms.
 

Asher Kelman

OPF Owner/Editor-in-Chief
How to get safe, but great body defense learning “training” of dangerous organisms for protecting us?

1. Natural versions from other species of animals. For example, Cowpox can train the body to subsequently defeat Smallpox

2. Laboratory grown variants of animal microbes that are cousins of debgetlus infectious organisms, for example the French developed vaccine against tuberculosis, BCG, Bacille Calmette Guèrin, originally for cows, that many Europeans have had with a consequent indented 1cm button scar on an upper arm!

3. Heat-treated or chemically inactivated purified organisms such as the Salk Polio Vaccime

to be continued!

Asher
 

Asher Kelman

OPF Owner/Editor-in-Chief
Yes, it’s important to mention Pasteur

He was a very brilliant but very flawed man like all of us but much better and far worse!

Very important, but not at the painstakingly brilliant level of Madame Curie for a noble role in modern medicine
 

Asher Kelman

OPF Owner/Editor-in-Chief
Mistakes:

1. Pasteur’s Rabies vaccine was given to a boy,,without adequate testing in animals. Only 7 dogs had been used in tests. Pasteur was not a physician qualified to administer the shot and was brought for the French Professional Scientists for account.

it turned out that the shot to thr boy didn’t protect the boy as the Rabies challenge was too weak!

2.Early batches of the Albert Sabin’s ORAL LIVE attenuated vaccine, was contaminated by a live monkey virus, which could have been a disaster!

BTW, I still have Sabin’s original desk. My children didn’t receive Sabin’s oral vaccine. Instead being cautious, and against live virus vaccines, I got them the competing Salk polio vaccine, (which is inactivated), that I imported from Canada!
 
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Asher Kelman

OPF Owner/Editor-in-Chief
Today’s Anti-virus Vaccines!

With the technologies of rapid and accurate DNA sequencing, the risk of contaminating extra viruses is close to non-existent.

1. Lots of pure surface virus building blocks in a stabilizing safe medium. NOT EFFICIENT

2. The instructions to make lots of pure virus surface building blocks suitable packaged

A. mRNA (Moderna and Pfizer vaccines), the string of nucleoside bases that code for the targeted virus surface components. This needs a delivery vehicle. Manufacturers use mixtures of lipids, (fats), to form spherules of a lipid envelope containing and protecting the precious and otherwise vulnerable and fragile mRNA.

All the packages need to do is fuse with the cell surface membrane of muscle cells at the injection site. Ribosomes will grab them and immediately produce endless copies of the virus surface protein and that will be shed and picked up by the body’s immune system to trigger immunity. Voila “ Success!!”

B. DNA (Astra Zeneca, China, Russia and scores of onstructed in a sequence the 4 bases, (Adenine, Thymine, Guanine and Cytosine), that codes for the mRNA in “A” above.

This has to be packed or else will be destroyed by enzymes. It has to get to the nucleus of muscle cells in the injection site.
i) using a modified human or animal adenovirus, (suitably altered in coding so it can’t produce disease). But it does reach the nucleus of muscle cells and the DNA is translated to many copies of mRNA which flood the cytoplasm of the muscle cells and hence to the ribosomes again producing thousands of copies of virus coat protein antigens. Again success!

Asher
 

James Lemon

Well-known member
Today’s Anti-virus Vaccines!

With the technologies of rapid and accurate DNA sequencing, the risk of contaminating extra viruses is close to non-existent.

1. Lots of pure surface virus building blocks in a stabilizing safe medium. NOT EFFICIENT

2. The instructions to make lots of pure virus surface building blocks suitable packaged

A. mRNA (Moderna and Pfizer vaccines), the string of nucleoside bases that code for the targeted virus surface components. This needs a delivery vehicle. Manufacturers use mixtures of lipids, (fats), to form spherules of a lipid envelope containing and protecting the precious and otherwise vulnerable and fragile mRNA.

All the packages need to do is fuse with the cell surface membrane of muscle cells at the injection site. Ribosomes will grab them and immediately produce endless copies of the virus surface protein and that will be shed and picked up by the body’s immune system to trigger immunity. Voila “ Success!!”

B. DNA (Astra Zeneca, China, Russia and scores of onstructed in a sequence the 4 bases, (Adenine, Thymine, Guanine and Cytosine), that codes for the mRNA in “A” above.

This has to be packed or else will be destroyed by enzymes. It has to get to the nucleus of muscle cells in the injection site.
i) using a modified human or animal adenovirus, (suitably altered in coding so it can’t produce disease). But it does reach the nucleus of muscle cells and the DNA is translated to many copies of mRNA which flood the cytoplasm of the muscle cells and hence to the ribosomes again producing thousands of copies of virus coat protein antigens. Again success!

Asher
Thank you for sharing this knowledge Asher.! The DNA is a two step process from what I have understood but also are there any added benefit as opposed to the RNA. Like say less chance of infection or something like that? Can you compare any significant differences between the DNA verses the RNA. I realize that neither of these vaccines will edit your genes but some of the people I talk with have some crazy ideas about these things. Of course we are not scientists but I would like to glean a bit more from your expertise in this field if possible ?
 
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Asher Kelman

OPF Owner/Editor-in-Chief
The DNA, naked, is far more stable environmentally than mRNA which can be broken down by enzymes on your hands.

In the body, there has to be a method to direct DNA into the nucleus of cells, as everywhere else it will be chewed up. A “Taxi” virus transport system gets it to the right cellular location!

mRNA in a lipid bioengineered-spherules or DNA, (coding for that mRNA), sneaked into a crippled virus, the coded content is the same!

mRNA vaccines provide for translation to proteins directly from ONLY the mRNA copies that are actually injected into the arm muscle cells!

DNA vaccines, however, potentially can produce many, many more thousands of copies as the inactivated/weak virus that is the transport “taxi” carries with it code for polymerases to transcribe thousands of copies of the “passenger“ vaccine DNA as vaccine mRNA which now leaves the nucleus and floods the cytoplasm and gets grabbed by ribosomes and so manufacture of virus antigen is enormous!

So there should be an advantage.

Surprisingly, however, mRNA vaccines hold their own.

I am totally confident they all the Westen Nations vaccines are extraordinarily “safe & effective” and likely the Russian Sputnik Vaccine, too, despite our limited review capabilities.

[The Chinese vaccine has no peer reviewed data as of yet, that I know of, but vaccines by dictatorships on mass populations and non-transparent data is problematic in ethics and reliability and not respected here in the Western Cultures]

There are, today, no known systemic risks in the modern biotechnology derived vaccines. The live vaccines of China hold the hazard of contaminating animal virus because we don’t know their ethical guidelines for fastidiousness.

Beyond doubt, the simplest and purists vaccines are the nanotechnology vaccines of designer mRNA packed in lipid spherules. Don’t need a virus “Uber“ or “Taxl” to get into the right place in the cell and are ready to work WITHOUT A SECONDS DELAY!

DIFFERENCE ARE THOS IN STORAGE AND STABILITY: The practical differences are the thermal stability of the designer lipid envelopes and the nature of additive to ensure the precious engineered packages survive transport on many flights and trucks to each person’s arm!

Likely as not, one could take double or quadruple doses of the Western vaccines without any harm. I would jump at getting a third jab of Moderna vaccine, and I would finf it worthwhile to me, up to $2,000, to get a 3rd shot. Why, because for me, 99% TOTAL protection from any morbidity is NOT up to what I would like for myself!
 

James Lemon

Well-known member
The DNA, naked, is far more stable environmentally than mRNA which can be broken down by enzymes on your hands.

In the body, there has to be a method to direct DNA into the nucleus of cells, as everywhere else it will be chewed up. A “Taxi” virus transport system gets it to the right cellular location!

mRNA in a lipid bioengineered-spherules or DNA, (coding for that mRNA), sneaked into a crippled virus, the coded content is the same!

mRNA vaccines provide for translation to proteins directly from ONLY the mRNA copies that are actually injected into the arm muscle cells!

DNA vaccines, however, potentially can produce many, many more thousands of copies as the inactivated/weak virus that is the transport “taxi” carries with it code for polymerases to transcribe thousands of copies of the “passenger“ vaccine DNA as vaccine mRNA which now leaves the nucleus and floods the cytoplasm and gets grabbed by ribosomes and so manufacture of virus antigen is enormous!

So there should be an advantage.

Surprisingly, however, mRNA vaccines hold their own.

I am totally confident they all the Westen Nations vaccines are extraordinarily “safe & effective” and likely the Russian Sputnik Vaccine, too, despite our limited review capabilities.

[The Chinese vaccine has no peer reviewed data as of yet, that I know of, but vaccines by dictatorships on mass populations and non-transparent data is problematic in ethics and reliability and not respected here in the Western Cultures]

There are, today, no known systemic risks in the modern biotechnology derived vaccines. The live vaccines of China hold the hazard of contaminating animal virus because we don’t know their ethical guidelines for fastidiousness.

Beyond doubt, the simplest and purists vaccines are the nanotechnology vaccines of designer mRNA packed in lipid spherules. Don’t need a virus “Uber“ or “Taxl” to get into the right place in the cell and are ready to work WITHOUT A SECONDS DELAY!

DIFFERENCE ARE THOS IN STORAGE AND STABILITY: The practical differences are the thermal stability of the designer lipid envelopes and the nature of additive to ensure the precious engineered packages survive transport on many flights and trucks to each person’s arm!

Likely as not, one could take double or quadruple doses of the Western vaccines without any harm. I would jump at getting a third jab of Moderna vaccine, and I would finf it worthwhile to me, up to $2,000, to get a 3rd shot. Why, because for me, 99% TOTAL protection from any morbidity is NOT up to what I would like for myself!
Thank you for your in depth explanation.. much appreciated! You mentioned ethics and I don’t want to steer your thread in any other direction. Do you think there should be an avenue for the big players to enter into license agreements with others?
 

Asher Kelman

OPF Owner/Editor-in-Chief
Thank you for your in depth explanation.. much appreciated! You mentioned ethics and I don’t want to steer your thread in any other direction. Do you think there should be an avenue for the big players to enter into license agreements with others?
I don’t see any ethical problems unless someone wants to import the Chinese Vaccine. I want to know if the used slave laborer for the research before the army.

In the West, we have overlapping methods, starting from every individual academic institution. Each had an ethic committee, (albeit with external religious leaders that hardly are qualified to be experts on ethics and morality since they rely on self-serving prejudice).

There are so many layers of review checking for faire representativeOf all communities in being tested to those who receive the vaccine.

As long as the distribution remains equitable, I would be happy. Let people make a profit!

Just reinvest the money in the countries vaccinated! We want all markets flourishing.

Asher
 
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