How many doses

[James Lemon]

OTOH, it’s 30% less effective AFAIK!

Not necessarily less effective Asher! A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic. The trials are ongoing and they are also testing the effect of a vaccine when given as two doses.

Just as with other adenovirus-based COVID-19 vaccines, the weakened adenovirus expresses the SARS-CoV-2 spike protein.


Researchers reported on July 30 in the journal Nature that a single shot of the Ad26 vaccine protected rhesus macaques from infection with SARS-CoV-2. In this study, the scientists tested seven slightly varying types of Ad26 vaccine prototypes and identified the one that produced the highest number of neutralizing antibodies. After receiving the chosen variant, the monkeys were then exposed to the coronavirus. Six out of seven monkeys that were given this prototype vaccine, calledAd26.COV2.S, and then exposed to the coronavirus showed no detectable virus in the lower respiratory tract and one showed very low levels in the nose, according to a statement.

A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials.

https://www.nature.com/articles/s41...45_deeplink_PID100052172&utm_content=deeplink

https://www.livescience.com/most-pr...on-johnson-s-janssen-pharmaceutical-companies

 

[Asher Kelman]

James,

No need to try to teach a virologist virology. I am up to date!

 

[James Lemon]

James,

No need to try to teach a virologist virology. I am up to date!

Well then you should explain on what criteria you base your claims on in regards to efficiency? Especially when it is clear to layman like myself that each of these vaccines come with some pretty significate baggage.

 

[Asher Kelman]

Well then you should explain on what criteria you base your claims on in regards to efficiency? Especially when it is clear to layman like myself that each of these vaccines come with some pretty significate baggage.

Since you looked at monkey trials with 6 of 7 being protected, now look at the Phase two and three trials with humans!

In fact the single dose vaccine is being tried in combination with a different MFR vaccine Russia to try to make it match the mRNA vaccines by Moderna and Pfizer.

I only put the bottom status for decision making for us.

I value your contributions. Mostly the pictures which are original and most valued.

Asher

 

[James Lemon]

Since you looked at monkey trials with 6 of 7 being protected, now look at the Phase two and three trials with humans!

In fact the single dose vaccine is being tried in combination with a different MFR vaccine Russia to try to make it match the mRNA vaccines by Moderna and Pfizer.

I only put the bottom status for decision making for us.

I value your contributions. Mostly the pictures which are original and most valued.

Asher

I think we’re going to need multiple different types of vaccines.

 

[Asher Kelman]

I think we’re going to need multiple different types of vaccines.

James,

Of course! There are over 180 vaccines currently in progress. One dropped out, thr very promising Australia candidate. It’s production capability we need and unless that is financed like fighter planes or missile defense as national security budget items or internationally like pay for the U.N. , we don’t have infrastructure in place to make billions of dose BEFORE worse variants evolve!

This is not a commercial venture but a military one, except the clever enemy is alien, an invading virus that recruits our own population to infect and kill us!

Asher

 

[James Lemon]

James,

Of course! There are over 180 vaccines currently in progress. One dropped out, thr very promising Australia candidate. It’s production capability we need and unless that is financed like fighter planes or missile defense as national security budget items or internationally like pay for the U.N. , we don’t have infrastructure in place to make billions of dose BEFORE worse variants evolve!

This is not a commercial venture but a military one, except three enemy is alien, an invading virus!

Asher

AstraZeneca, which has pledged it won't make a profit on the vaccine during the pandemic, has reached agreements with governments and international health organizations that put its cost at about $2.50 a dose. Pfizer's vaccine costs about $20, while Moderna's is $15 to $25, based on agreements the companies have struck to supply their vaccines to the U.S. government.
Oxford vaccine's simpler supply chain and AstraZeneca's commitment to provide it on a non-profit basis during the pandemic mean it will be affordable and available to people around the world.
From the beginning of their collaboration with AstraZeneca, Oxford scientists have demanded that the vaccine be made available equitably to everyone in the world so rich countries can't corner the market as has happened during previous pandemics.

https://www.ctvnews.ca/health/coron...e-shown-to-be-effective-and-cheaper-1.5200355

 

[Asher Kelman]

We know that! However it’s a drop in the ocean compared to what we need. We simply don’t have global MFR capacity. Commercial companies are not massive enough! In two years they will cover only Western Societies and we will have by then another 10 aggressive variants.

TO PREVENT VARIANTS WE NEED TO LIMIT NUMBER OF PEOPLE NEWLY INFECTED.

That means a tenfold increase in mass production!

It’s not science or the companies we need but a military operation!

Asher

 

[Asher Kelman]

None of these differences of vaccine efficacy matter much, right now, as we lack 95% of the needed manufacturing capacity to control the current virus variants attacking us!

We must face the fact that we, as nation states, don’t think this is important to our competing societies as we do, the ~$50 billion 250,000 gas centrifuges, we each routinely finance, without hesitation or much debate, to manufacture nuclear bombs!

We don't need new science or technology. We only need managers with merely the training of high school science teachers and then just military commitment with defense production power focused on defeating the enemy.

Obviously we are nowhere near the focus and commitment needed and so infection of hundreds of millions of people will deliver us more hazardous variants which eventually will bypass vaccines As we are simply too slow!

Asher

 

[James Lemon]

We know that! However it’s a drop in the ocean compared to what we need. We simply don’t have global MFR capacity. Commercial companies are not massive enough! In two years they will cover only Western Societies and we will have by then another 10 aggressive variants.

TO PREVENT VARIANTS WE NEED TO LIMIT NUMBER OF PEOPLE NEWLY INFECTED.

That means a tenfold increase in mass production!

It’s not science or the companies we need but a military operation!

Asher

Sounds narcotic and

None of these differences of vaccine efficacy matter much, right now, as we lack 95% of the needed manufacturing capacity to control the current virus variants attacking us!

We must face the fact that we, as nation states, don’t think this is important to our competing societies as we do, the ~$50 billion 250,000 gas centrifuges, we each routinely finance, without hesitation or much debate, to manufacture nuclear bombs!

We don't need new science or technology. We only need managers with merely the training of high school science teachers and then just military commitment with defense production power focused on defeating the enemy.

Obviously we are nowhere near the focus and commitment needed and so infection of hundreds of millions of people will deliver us more hazardous variants which eventually will bypass vaccines As we are simply too slow!

Asher

Nobody said that any vaccine would stop transmission. Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”

 

[Asher Kelman]

Sounds narcotic and


Nobody said that any vaccine would stop transmission. Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”

Sounds narcotic and


Nobody said that any vaccine would stop transmission. Pfizer chairman Albert Bourla told Dateline host Lester Holt that the pharmaceutical company was “not certain” if the vaccine prevented the coronavirus from being transmitted, saying, “This is something that needs to be examined.”

You keep going to details. Not important.

Any of the 180 + vaccines no doubt will stop transmission, once we overwhelm it. “Which vaccine?” is so unimportant.

Right now, except for Israel, vaccination is 1/10 of what it should be and that excludes most of the world which is 1000 times worse. Details of any vaccine are not relevant now. They all are going to be good enough when we make enough!

Only two things to focus on: MASSIVE WAR STATUS production and how to get it into arms.

Asher

 

[James Lemon]

You keep going to details. Not important.

Any of the 180 + vaccines no doubt will stop transmission, once we overwhelm it. “Which vaccine?” is so unimportant.

Right now, except for Israel, vaccination is 1/10 of what it should be and that excludes most of the world which is 1000 times worse. Details of any vaccine are not relevant now. They all are going to be good enough when we make enough!

Only two things to focus on: MASSIVE WAR STATUS production and how to get it into arms.

Asher

You keep going to details. Not important.

Any of the 180 + vaccines no doubt will stop transmission, once we overwhelm it. “Which vaccine?” is so unimportant.

Right now, except for Israel, vaccination is 1/10 of what it should be and that excludes most of the world which is 1000 times worse. Details of any vaccine are not relevant now. They all are going to be good enough when we make enough!

Only two things to focus on: MASSIVE WAR STATUS production and how to get it into arms.

Asher

None of the trials currently under way are designed to detect a reduction in any serious outcome such as hospital admissions, use of intensive care, or deaths. Nor are the vaccines being studied to determine whether they can interrupt transmission of the virus.

 

[Asher Kelman]

None of the trials currently under way are designed to detect a reduction in any serious outcome such as hospital admissions, use of intensive care, or deaths. Nor are the vaccines being studied to determine whether they can interrupt transmission of the virus.

Not true. But again none of that matters. Any of the vaccines will do all of the above anyway!

Again all unimportant minutiae not to be concerned about. Either we have massive MFR or this lasts 4-5 years!

Asher

 

[James Lemon]

Not true. But again none of that matters. Any of the vaccines will do all of the above anyway!

Again all unimportant minutiae not to be concerned about. Either we have massive MFR or this lasts 4-5 years!

Asher

I wouldn't worry about it. We are not planet a full of immunocompromised people.

 

[Asher Kelman]

I wouldn't worry about it. We are not planet a full of immunocompromised people.

Of course you wouldn’t worry about it!

That statement tells everything there is to know!

 

[Alex Johnson]

I have checked this thoroughly.

CDC has authorized the 6 doses where the last one is 1.0 ml.

The Pharmaceutical company doesn’t care. Their profits are enough.

UCLA in and the Los Angeles County do get 6 doses.

Yes, it’s feasible to give a lesser portion in the first dose, but we are not doing that in Southern California.

Asher

I am not an expert and do not work in the medical field. I just suggested one of the options. But if there is no problem with that, oh why not. If you can get 6 full doses of vaccine from one bottle of the drug - great!

 

[Asher Kelman]

I am not an expert and do not work in the medical field. I just suggested one of the options. But if there is no problem with that, oh why not. If you can get 6 full doses of vaccine from one bottle of the drug - great!

I think the dose may be 0.3 ml or according to how ts silted, but now Astra Zeneca s charging they uS government for that extra dose as the contract was “per dose”, so they have earned it!

Asher

 

[James Lemon]

Single dose.

https://www.bbc.com/news/health-55857530

 

[nicolas claris]

What we learn from the massive vaccination campaign in Israel?

In the vaccination race, Israel is in pole position. It is the country that has vaccinated the most since the beginning of the epidemic in proportion to its population, which makes it an open-air laboratory that is highly scrutinized by other countries.
…
How many people are already vaccinated in Israel?

Between the launch of the vaccination campaign on December 19 and January 29, nearly 3 million Israelis had received a dose of vaccine. In detail, nearly 32 percent received the first dose and 18 percent received both doses. This progress is much faster than in any other country, although not all started on the same date: the United Arab Emirates vaccinated 29 percent of its population, the United Kingdom 12 percent, and France 2 percent, according to Our World in Data projections.
…
"We are seeing very encouraging results in people over 60 years of age, such as a 50% reduction in the number of infections after a single dose, a 60% reduction in the number of hospitalizations or a very limited number of cases in people who received 2 doses, which confirms the high level of efficacy suggested by the clinical trials. »
Antoine Flahault, Director of the Institute of Global Health at the Faculty of Medicine of the University of Geneva, is equally optimistic:
"The Israeli experience confirms the significant efficacy of the Pfizer-BioNTech messenger RNA vaccine, from the first dose, fifteen days after its administration, but also its excellent tolerance. »

Source
Translated from French by Deepl

 

[James Lemon]

What we learn from the massive vaccination campaign in Israel?

In the vaccination race, Israel is in pole position. It is the country that has vaccinated the most since the beginning of the epidemic in proportion to its population, which makes it an open-air laboratory that is highly scrutinized by other countries.
…
How many people are already vaccinated in Israel?

Between the launch of the vaccination campaign on December 19 and January 29, nearly 3 million Israelis had received a dose of vaccine. In detail, nearly 32 percent received the first dose and 18 percent received both doses. This progress is much faster than in any other country, although not all started on the same date: the United Arab Emirates vaccinated 29 percent of its population, the United Kingdom 12 percent, and France 2 percent, according to Our World in Data projections.
…
"We are seeing very encouraging results in people over 60 years of age, such as a 50% reduction in the number of infections after a single dose, a 60% reduction in the number of hospitalizations or a very limited number of cases in people who received 2 doses, which confirms the high level of efficacy suggested by the clinical trials. »
Antoine Flahault, Director of the Institute of Global Health at the Faculty of Medicine of the University of Geneva, is equally optimistic:
"The Israeli experience confirms the significant efficacy of the Pfizer-BioNTech messenger RNA vaccine, from the first dose, fifteen days after its administration, but also its excellent tolerance. »

Source
Translated from French by Deepl

I think its fair to say that we need several solutions. Our Canadian leaders are failing miserably by trying to procure 400 million doses in the early stages for a population of 38 million. However they are either bad at arithmetic or just greedy I don't know the rational ?
Most of the world’s leaders, including Australia’s Prime Minister Scott Morrison, have stated that a successful COVID-19 vaccine should be shared equitably.

 

[Asher Kelman]

I don’t think it matters much, if we are fast, which vaccines are used. However if we are slow, then the new variants will have time to replace the ones we can more easily control.

Israel has 100% of its populationin 3 health plans with 100% data of past illnesses, medicines, allergies and immunizations. Also, in times of real crisis the people follow the State’s rules pretty well.

So it’s relatively easy to track who has received vaccine and who needs it, next by priority.

The only block is supply of vaccine. Well Israel licensed everything they could get data for analysis and paid whatever price the market demanded and even offered all the immunization data back to thr manufacturers, in return for guaranteed supply.

So the drug companies have a 9 million size data pool with racial diversity: Caucasian, Israeli Arab, Israeli Black, North African, Greek, Armenian, Assyrian and more.

The benefits to drug companies, governments and the World Health Organization are enormous as Israel uses various vaccines in diverse populations, age groups and health profiles.

However, it does give Israel a privilege position in getting vaccine way ahead of other countries who have not gotten their act together.

Any country like the USA, Canada, France, Germany or the UK could have gone one step further and taken over related industrial plants and put the needed resources into vaccine production. The level of science is not the challenge, just the industrial strength of a nation and its will.


Asher

 

[Asher Kelman]

Barriers to getting vaccine!


France, by example, with yellow vests and others distrusting the government, would suspect vanilla icecream if it was distributed by the government for free!

In Israel however, “there are almost more doctors than bus drivers”, and health care is totally respected as part of Gods benevolence and each persons enter right.

So countries with natural cynics and training in free thoughts and philosophy, like France, are going to face a much longer duration of civil hell, as vaccines are taken with much resentment!

Equitable Sharing!

Poorer countries, unfortunately will have to wait in line. Hopefully, some populations will have been already partially immunized decades ago with “uncharacterized” but related coronaviruses that could offer some “innate” protection!

 

[Alex Johnson]

Barriers to getting vaccine!


France, by example, with yellow vests and others distrusting the government, would suspect vanilla icecream if it was distributed by the government for free!

In Israel however, “there are almost more doctors than bus drivers”, and health care is totally respected as part of Gods benevolence and each persons enter right.

So countries with natural cynics and training in free thoughts and philosophy, like France, are going to face a much longer duration of civil hell, as vaccines are taken with much resentment!

Equitable Sharing!

Poorer countries, unfortunately will have to wait in line. Hopefully, some populations will have been already partially immunized decades ago with “uncharacterized” but related coronaviruses that could offer some “innate” protection!

Sooner or later we will all get our vaccine. Of course, poor countries will have to wait longer. This is the disadvantage. But what can you do? The leading countries are already devils when they ordered their vaccines. It makes sense that they are the first to receive it. After all, they gave money for its development (paying for a pre-order for the vaccine). We just have to wait until the turn comes to other countries that were not able to place an order earlier. Of course, the WHO oversees the vaccine distribution program, but very few doses are distributed under this program so far.

 

[Asher Kelman]

Sooner or later we will all get our vaccine. Of course, poor countries will have to wait longer. This is the disadvantage. But what can you do? The leading countries are already devils when they ordered their vaccines. It makes sense that they are the first to receive it. After all, they gave money for its development (paying for a pre-order for the vaccine). We just have to wait until the turn comes to other countries that were not able to place an order earlier. Of course, the WHO oversees the vaccine distribution program, but very few doses are distributed under this program so far.

It’s far worse.

With fighter planes, warships and missile defense, we can protect our OWN country as a fortress.

The virus, however is Ike a Bitcoin mining operation. With the virus, every 3 new infection instances changes one base in the base sequence of the virus. Every 1 million to 10 million such changes delivers a virus changed enough to be worse for humans.

So it’s like having enormous arrays of computers seeking Bitcoin by requesting from software another chance at finding a Bitcoin.

With a few countries fortresses against the earlier dominant virus strains, the rest of the world is mining itself for NEW novel variants, but there are billions more unprotected people outside of advanced countries, so once again,a few infected travelers will for sure import the new variants to countries that have immunity to the earlier variants.

Unless the whole world is immunized, the USA and all other rich countries are powerless to protect their populations against ever-more-virulent emerging Covid variants.

Asher

 

[Jerome Marot]

France, by example, with yellow vests and others distrusting the government, would suspect vanilla icecream if it was distributed by the government for free!

I don't think this is quite true. Time will tell, of course.

 

[Asher Kelman]

I don't think this is quite true. Time will tell, of course.

Remember, I only read US and BBC news of France and that filtration is likely biased. For French I rarely go to primary French sources, which would give me a deeper insight!

Asher